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CBD (Cannabidiol) oil is derived from hemp.
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Marijuana is cultivated primarily for its psychoactive cannabinoid, a chemical
compound called tetrahydrocannabinol or THC, for recreational and medicinal
use. Marijuana contains both THC and CBD.
Hemp contains only a trace of THC, less than 0.3% compared to marijuana's
hefty 5-35%. The main cannabinoid in hemp is CBD, but there are over 100
other cannabinoids in hemp, as well as compounds that produce tastes and
scents called terpenes (e.g. citrusy smell of oranges, unique aroma of pine
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For thousands of years, hemp has been cultivated for food, clothing, fiber, and
fuel. It is one of the world's oldest domesticated crops. In the early days, hemp
was a vital crop in the U.S. During the 1700s, colonial farmers grew hemp
mainly for its strong fiber.
However, hemp production came to a screeching halt when the Marijuana Tax
Act of 1937 was passed. Mainstream attitudes towards cannabis began to
sway greatly towards the negative. Hemp became the "evil weed" because it
shares the same species as marijuana even though it does not contain
marijuana's abundant THC.
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Over the years, many have speculated that the real reason for the anti-
cannabis campaign boiled down to the worry that hemp could become a low-
cost substitute for paper pulp. American industrialist William Randolph Hearst
and the DuPont family had major investments in the timber and newspaper
industries. They initiated a smear campaign to destroy the lucrative hemp
market for fear that the rise of hemp would undercut their profits.
Nevertheless, years later, it became known that hemp does not contain a high
enough concentration of cellulose to be an effective paper substitute.
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Eighty long years later, hemp finally regained its legal status in the U.S. after
the passage of the 2018 Farm Bill. Hemp, defined as cannabis with less than
0.3% THC, is removed from Schedule I controlled substances. Hemp-derived
products are legal as long as they come from licensed hemp growers. More
and more universities and hospitals have begun to study it. Americans can
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Marijuana laws are also changing at a rapid pace across America. Even though
it is still illegal on the federal level, many states have legalized marijuana. For
the remaining states, some have allowed it for medical use and some
recreational use.
Cannabinoids made by our own bodies are called endocannabinoids (the
prefix "endo" means within). In the 1990s, researchers made an astonishing
discovery that the ECS plays a major role in our overall health.
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This communication involves messenger molecules called endocannabinoids
and cannabinoid receptors on every cell that accepts them. Think of it as a
"key and lock" system. The receptors are locks and the endocannabinoids are
keys that bind to these receptors and unlock them.
There are two main types of receptors within the ECS - cannabinoid receptor
type 1 (CB1) and cannabinoid receptor type 2 (CB2).
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Researchers found more than 1,000 receptors in the body. CB1 receptors are
located largely on nerve cells in the brain and spinal cord, as well as the eye
and retina. CB2 receptors are predominantly found in the immune system
and in the organs and tissues, such as brain, spleen, blood cells,
gastrointestinal, and urinary tracts.
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The body produces two types of
endocannabinoids - anandamide and 2-AG.
These are transported into the cells through
the CB1 and CB2 receptors. As we age, the
body becomes less efficient in producing
anandamide and 2-AG. The proper
functioning of the ECS also depends on the
adequacy of omega-3 in the diet.
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Many people have experienced the feel good sensation or "high" after
strenuous exercise. The lifted mood comes from the release of endorphins.
Researchers now know that it is also from an increase in anandamide, which
targets mainly the CB1 receptors and, to a lesser extent, the CB2 receptors.
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Researchers have now discovered that both endocannabinoids, anandamide
and 2-AG, have a considerable impact on a variety of functions including
appetite, energy and balance, immunity, memory, metabolism, nervous
system, sleep, and stress response.
The Cannabis plant contains over 100 cannabinoids. These compounds closely
resemble the human endocannaboids. The main cannabinoid in hemp is CBD,
and in marijuana, THC.
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Unlike THC, CBD does not bind directly into our cannabinoid receptors.
Nevertheless, it does stimulate the activity of both CB1 and CB2 receptors
without directly tapping into them. A study by the National Institute of Health
found that CBD causes the body to release more endocannabinoids, especially
2-AG. Moreover, CBD inhibits the degradation of anandamide.
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CBD may offer an option for treating different
types of chronic pain: fibromyalgia, gout, HIV,
multiple sclerosis, neuropathic, and
rheumatoid arthritis. Studies found that
applying CBD oil directly on the problem area
helps to lower pain and inflammation. CBD
works by impacting cannabinoid receptor
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CBD has been touted for a wide variety of health interests, but the strongest
scientific evidence is for its effectiveness in treating two rare drug-resistant
childhood epilepsy conditions, namely Lennox-Gastaut syndrome (LGS) and
Dravet syndrome (DS). The FDA has recently approved the first ever CBD-
derived drug Epidiolex for these conditions. In numerous studies, CBD was
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Researchers also found that subjects did not build up a tolerance to the
effects of CBD, so there was no need to increase dosage continually. Unlike
some pain medications, CBD is not addictive and does not have any
intoxicating effects, offering much relief for people who have chronic pain.
An oral spray called Sativex, which is a combination of CBD and THC, has been
approved in a number of countries in Europe and Canada (but not in the U.S.)
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Clinical trials have revealed that both marijuana and CBD may be effective in
reducing different forms of anxiety including generalized anxiety disorder,
panic disorder, social anxiety disorder, obsessive-compulsive disorder, and
post-traumatic stress disorder (PTSD).
Not only did participants in the studies felt better, they also reported reduced
cognitive impairment and anxiousness. Scientists suggest that in addition to
impacting the endocannabinoid system, CBD may influence receptors
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In addition, some studies showed that CBD
eases depression and helps with psychotic
disorders like schizophrenia. (Please note that
marijuana does not help with either and may
actually worsen psychosis.)
Researchers found that cancer patients
treated with CBD and THC, the psychoactive
compound from marijuana, experienced
significant reduction in pain. In addition, a
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administered via mouth spray reduced side
effects associated with cancer treatments like
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